Polycystin-1 induced apoptosis and cell cycle arrest in G₀/G₁ phase in cancer cells

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• 作者：Rong Zheng ; Zheng Zhang ; Xiaoyan Lv ; JunMing Fan ; Ye Chen ; Yidong Wang ; Ruizhi Tan ; Yuhang Liu ; Qin Zhou
• 关键词：Apoptosis ; Cell cycle ; Polycystin-1 ; Proliferation ; Wnt pathway
• 刊名：Cell Biology International
• 出版年：2008
• 期刊代码：164_10656995
• 类别：bio
• 出版时间：April 2008
• 卷：32
• 期：4
• 页码：427-435
• 文件大小：2365 K

摘要

Studies have shown that polycystin-1, encoded by PKD1, the major ADPKD, may have a central role in regulating both apoptosis and proliferation, which could prevent the malignant transformation of affected cells. However, as a putative tumor suppressor, direct studies on the possibility that polycystin-1 may play a role in cancer cells' biological properties have not yet been reported. We have demonstrated that the apoptosis of cancer cells was induced by overexpression of polycystin-1. After transfection with polycystin-1, three cancer cell lines, HepG2, A549, and SW480, showed significantly increased apoptosis compared with the respective control groups. This was accompanied by cell cycle arrest at G₀/G₁ phase, whereas cell proliferation was not significantly affected. Overexpression of polycystin-1 induces apoptosis in cancer cells, at least partially, through Wnt and a caspase-dependent pathway.