Rapid screening of poly(ethylene glycol) polymers by C₁₈ column-flow injection with piezoelectric detection system

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• 作者：Marí ; a R. Plata^a ; ^b ; Ana M. Contento^a ; Á ; ngel Rí ; os^a ; ^{angel.rios@uclm.es}
• 关键词：C18 column ; Piezoelectric quartz crystal (PQC) ; Poly(ethylene glycol) ; Routine sample analysis ; Screening
• 刊名：Microchemical Journal
• 出版年：2012
• 期刊代码：64_0026265x
• 类别：ce
• 出版时间：July, 2012
• 卷：103
• 期：Complete
• 页码：135-141
• 文件大小：512 K

摘要

A rapid and low cost analytical method for the screening and determination of poly(ethylene glycol)s polymers has been developed. Several initial studies were carried out in order to demonstrate the utility of a piezoelectric quartz crystal as a detection system for the quantification of poly(ethylene glycol)s. The method involves the use of a simple flow injection device connected to a piezoelectric quartz crystal detector. Several parameters associated with the simple flow injection manifold were optimized. Subsequently, this detector was coupled to a C₁₈ column and the best experimental conditions were investigated in order to perform the screening and determination of poly(ethylene glycol)s. The applicability of this method, as an analytical screening tool, was demonstrated by the characterization of samples with different molecular mass polymers without using HPLC and CE techniques to carry out oligomer separations. A standard curve to determine the polymer content was obtained by relating the resonance frequency shift and polymer concentration, which showed good linearity and good regression coefficients. The working range, repeatability, limit of detection and recovery were all acceptable for the analysis of the poly(ethylene glycol)s. Finally, the proposed method was applied to determine these polymers in several samples, such as pharmaceutical products, washing powder, detergents and a body spray.