BKV and JCV large T antigen-specific CD8+ T cell response in HLA A*0201+ kidney transplant recipients with polyomavirus nephropathy and patients with progressive multifocal leuko
- 作者：Yiping Chen ; Jennifer Trofe ; Jennifer Gordon ; Patrick Autissier ; E. Steve Woodle ; Igor J. Koralnik
- 关键词：BK virus ; JC virus ; Large T antigen ; Cytotoxic T lymphocytes ; Tetramer ; Polyomavirus nephropathy ; Progressive multifocal leukoencephalopathy
- 刊名：Journal of Clinical Virology
- 出版年：2008
- 期刊代码：150_13866532
- 类别：med
- 出版时间：June 2008
- 卷：42
- 期：2
- 页码：198-202
- 文件大小：200 K
摘要
BK virus (BKV), which causes polyomavirus-associated nephropathy (PVN) in kidney transplant recipients (KTx), has 75%homology with JC virus (JCV), the etiologic agent of progressive multifocal leukoencephalopathy (PML). The large T-antigen (T-ag) is the main regulatory protein of polyomaviruses that is expressed early in the viral cycle.