A further evaluation of the cognitive deficits associated with restless legs syndrome (RLS)
- 作者：Charlene E. Gamaldo ; Amy R. Benbrook ; Richard P. Allen ; Oluwamurewa Oguntimein ; Christopher J. Earley
- 关键词：Restless legs syndrome ; Cognition ; Sleep deprivation ; Chronic sleep restriction ; Polysomnogram ; Pre-frontal cortex ; Verbal Fluency test ; Trail Making test
- 刊名：Sleep Medicine
- 出版年：2008
- 期刊代码：241_13899457
- 类别：med
- 出版时间：July 2008
- 卷：9
- 期：5
- 页码：500-505
- 文件大小：101 K
摘要
Restless legs syndrome (RLS) is a common sensorimotor disorder that peaks in severity during the night and comes on with rest. As a result, this condition often results in significant chronic sleep loss, especially for those with severe disease. Chronic partial sleep restriction has been associated with conditions such as depression, anxiety, chronic pain, and decline in cognitive function. Furthermore, studies have found that RLS patients suffer from these conditions more than their unaffected peers. Thus, the morbidity rate associated with RLS has often been attributed to the chronic sleep loss that frequently accompanies this condition. However, no study has specifically compared RLS sufferers to otherwise normal sleep-restricted controls in order to assess disease morbidity independent of its sleep deprivation effects. In this study, we compared the cognitive function of RLS patients who were off treatment to sleep-restricted control subjects.