The haemocompatibility of polyurethane–hyaluronic acid copolymers

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• 作者：Fangmin Xu ; John C. Nacker ; Wendy C. Crone ; Kristyn S. Masters
• 关键词：Polyurethane ; Hyaluronic acid ; Haemocompatibility ; Thrombogenicity
• 刊名：Biomaterials
• 出版年：2008
• 期刊代码：7_01429612
• 类别：ms
• 出版时间：January 2008
• 卷：29
• 期：2
• 页码：150-160
• 文件大小：803 K

摘要

Despite decades of research into haemocompatible biomaterials, there remain surprisingly few materials that can be used in blood-contacting applications. We have synthesized copolymers of polyurethane (PU) with hyaluronic acid (HA) with the goal of creating materials that incorporate an inherently non-thrombogenic, biological component into the bulk polymer structure. HA was incorporated into the polymer backbone as a chain extender during PU synthesis, and the physical and biological properties of the resulting copolymer were directly controlled by the HA content. Increases in HA content led to a linear increase in hydrophilicity (R²=0.993) and corresponding increase in surface energy compared to PU controls. Elastic modulus also increased with HA content (p<0.001), while surface roughness did not significantly differ from PU controls for most PU&#x2013;HA formulations. Incorporation of HA resulted in negligible platelet adhesion to the PU&#x2013;HA (p<0.001), representing a 20-fold decrease in platelet adhesion compared to PU. Red blood cell adhesion also decreased with increasing HA content (p<0.001). The PU&#x2013;HA materials were cytocompatible and supported endothelial cell adhesion and viability. Thus, we have demonstrated the synthesis of a copolymer whose physical and biological properties are easily tailored, and whose potent anti-thrombogenic properties demonstrate its great promise for use in vascular applications.