The incidence of malignant melanoma during pregnancy has been estimated to be 0.1 to 2.8 per 1,000 pregnancies. In women with a history of melanoma, pregnancy does not seem to increase the risk of recurrence or to negatively influence survival. However, survival is approximately 6 months shorter in women with recurrent disease and those requiring treatment during pregnancy. Malignant melanoma is the most common type of cancer to metastasize to the placenta and fetus. We report the case of a pregnant woman with a history of melanoma who showed cerebral recurrence and died 21 days post-partum, without placental or fetal metastases.