Clinical, neuroendocrine and treatment studies of impulsive aggression
- 作者：Coccaro ; E.F.
- 刊名：Biological Psychiatry
- 出版年：1996
- 期刊代码：34_00063223
- 类别：med
- 出版时间：April 1, 1996
- 卷：39
- 期：7
- 页码：561
- 文件大小：118 K
摘要
Reduced central serotonin (5-HT) system function reflected by reduced concentrations of lumbar cerebrospinal fluid 5-hydroxyindolacetic acid or by altered hormonal responses to 5-HT challenge agents, has been associated with suicidal and impulsive aggressive behaviors in a variety of psychiatric patients, particularly those with personality disorders. In addition, there is emerging evidence of relationships between other neurotransmitter and these behaviors as well as their interaction with the 5-HT system. This presentation will review data from a variety of neurochemical, neuroendocrine, and clinical trial studies in psychiatric patients in which history of suicidal and/or impulsive aggressive behavior were used as independent variables. Among the variables which have been reported as correlating with suicidal and/or impulsive aggressive behavior are: a) CSF 5-HIAA, b) PRL Response to Fenfluramine Challenge, c) Platelet 5-HT Transporter/5-HT-2a Receptors; d) pMHPG and GH Response to Clonidine Challenge (Alpha-2 NE); e) CSF Vasopressin. While 5-HT appears to have an inhibiting influence on suicidal and impulsive aggressive behaviors, other neurotransmitter systems may play a role in facilitating these behaviors. An understanding of this more complex view of the biology of impulsive aggressiveness is important if one is to design pharmacologic treatment strategies.