Possible roles of Plexin-A4 in positioning of oligodendrocyte precursor cells in developing cerebral cortex

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• 作者：Atsumasa Okada^a ; ^b ; Yasuhiro Tomooka^a ; ^b ; ^{tomoylab@rs.noda.tus.ac.jp}
• 关键词：Oligodendrocyte precursor cells ; Plexin-A4 ; Sema6A ; Sema3A ; Migration ; Positioning
• 刊名：Neuroscience Letters
• 出版年：2012
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：16 May, 2012
• 卷：516
• 期：2
• 页码：259-264
• 文件大小：1763 K

摘要

Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased number of OPCs in both the upper- and middle-regions of the cortical plate, where both indirect- and direct-ligands of Plexin-A4, Sema3A and Sema6A, respectively, were continuously expressed, and (2) aberrant distributions of OPCs in both the intermediate zone and corpus callosum, where Plexin-A4 was richly expressed in wild-type mice. These results suggest that Plexin-A4 is involved in the precise positioning of OPCs in developing cerebral cortex.