Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat-related posttraumatic stress disorder

详细信息	查看全文 | 推荐本文 |

• 作者：Nela Pivac ; Jelena Knezevic ; Dragica Kozaric-Kovacic ; Martina Dezeljin ; Maja Mustapic ; Davor Rak ; Tanja Matijevic ; Jasminka Pavelic ; Dorotea Muck-Seler
• 关键词：Combat-related posttraumatic stress disorder ; MAO-B intron 13 polymorphism ; Platelet MAO-B activity ; Psychotic symptoms
• 刊名：Journal of Affective Disorders
• 出版年：2007
• 期刊代码：141_01650327
• 类别：med
• 出版时间：November 2007
• 卷：103
• 期：1-3
• 页码：131-138
• 文件大小：219 K

摘要

The neurobiology of posttraumatic stress disorder (PTSD) involves alterations in multiple neuroendocrine and neurotransmitter systems. Platelet monoamine oxidase (MAO-B) has been associated with susceptibility to various psychiatric disorders, personality traits and behaviors.

Methods

Platelet MAO-B activity and MAO-B intron 13 polymorphism (a G/A substitution) were determined in male war veterans (n = 106) with DSM-IV diagnosed current and chronic PTSD, divided into subgroups of PTSD patients with (n = 28) or without (n = 78) psychotic features, combat exposed veterans (n = 41) who did not develop PTSD, and healthy control men (n = 242).

Results

Two-way ANOVAs revealed a significant effect of diagnosis and smoking, a significant effect of smoking, no significant effect of genotype, and no significant interaction between genotype, smoking or diagnosis, on platelet MAO-B activity. One-way ANOVAs showed significantly lower platelet MAO-B activity in smokers than in nonsmokers. After controlling for smoking, veterans with psychotic PTSD had significantly higher platelet MAO-B activity than veterans with or without PTSD, or healthy subjects.

Limitations

The results were obtained on peripheral biochemical marker, i.e. platelet MAO activity.

Conclusions

The MAO-B intron 13 polymorphism was not functional, and did not affect platelet MAO-B activity. The allele frequencies of the MAO-B genotype were similarly distributed among healthy controls and veterans with or without PTSD and/or psychotic symptoms. The results suggest that platelet MAO-B activity, controlled for smoking status, might be used as a peripheral marker of the psychotic symptoms in PTSD.