Abnormal event-related potentials in young and middle-aged adults with the ApoE 蔚4 allele

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• 作者：Krystin Corby^a ; Charlie D. Morgan^a ; Claire Murphy^a ; ^b ; ^{cmurphy@sciences.sdsu.edu}
• 关键词：Age ; Event-related potentials ; P3 ; Visual ; Olfaction ; Smell ; Smell impairment
• 刊名：International Journal of Psychophysiology
• 出版年：2012
• 期刊代码：33_01678760
• 类别：psy
• 出版时间：March, 2012
• 卷：83
• 期：3
• 页码：276-281
• 文件大小：727 K

摘要

The largest genetic susceptibility factor for Alzheimer's disease is the Apolipoprotein E (ApoE) 蔚4 allele. Cognitive decline and olfactory impairment are greater in those positive for the 蔚4 allele. This study sought to determine if the olfactory event-related potential (OERP), compared to the visual ERP, would be sensitive to these subtle declines. Participants included 40 individuals from two age groups, half of each group were 蔚4 allele positive and half were 蔚4 negative. Visual ERPs did not demonstrate significant differences between ApoE groups. OERPs demonstrated robust age by ApoE interactions. P3 latencies were significantly longer in 蔚4 young and middle age participants. These findings suggest that very early olfactory and cognitive changes related to ApoE status are detectible via the OERP.