Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task
- 作者：Jean-Charles Bizot ; Alexandre Herpin ; Sté ; phanie Pothion ; Sylvain Pirot ; Fabrice Trovero and Hé ; lè ; ne Ollat
- 关键词：DNMTS ; Episodic memory ; Object recognition ; Radial maze ; Rat ; Sulbutiamine ; Working memory
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：2005
- 期刊代码：222_02785846
- 类别：med
- 出版时间：2005
- 卷：29
- 期：6
- 页码：928-935
- 文件大小：127 K
摘要
The effect of a sulbutiamine chronic treatment on memory was studied in rats with a spatial delayed-non-match-to-sample (DNMTS) task in a radial maze and a two trial object recognition task. After completion of training in the DNMTS task, animals were subjected for 9 weeks to daily injections of either saline or sulbutiamine (12.5 or 25 mg/kg). Sulbutiamine did not modify memory in the DNMTS task but improved it in the object recognition task. Dizocilpine, impaired both acquisition and retention of the DNMTS task in the saline-treated group, but not in the two sulbutiamine-treated groups, suggesting that sulbutiamine may counteract the amnesia induced by a blockade of the N-methyl-d-aspartate glutamate receptors. Taken together, these results are in favor of a beneficial effect of sulbutiamine on working and episodic memory.