We obtained 30 patient-specific geometries (mean age 67.1 (卤9.2) years, all with stable angina) of the LCA using dual-source computed tomography and virtually removed any plaque present. We then performed computational fluid dynamics simulations to calculate the wall shear parameters.
For the 96 total plaques, AWSS had a higher sensitivity for the prediction of plaque locations (86 卤 25%) than AWSSG (65 卤 37%, p < 0.05), OSI (67 卤 32%, p < 0.01) or RRT (48 卤 38%, p < 0.001). RRT had a higher PPV (49 卤 36%) than AWSS (31 卤 20%, p < 0.05) or AWSSG (16 卤 12%, p < 0.001). Segment 5 of the LCA presented with overall low values for sensitivity and PPV. Parameter performance in the remainder of the LCA was comparable to that in the RCA.
AWSS features remarkably high sensitivity, but does not reach the PPV of RRT. This may indicate that while low wall shear stress is necessary for plaque formation, its presence alone is not sufficient to predict future plaque locations. Time dependent factors have to be taken into account as well.