In vitro effect of PPAR-γ2 Pro12Ala polymorphism on the deposition of Alzheimer's amyloid-β peptides
- 作者：Cristina d'Abramo ; Jean-Marc Zingg ; Antonio Pizzuti ; Francesca Argellati ; Maria A. Pronzato ; Roberta Ricciarelli
- 关键词：Alzheimer's disease ; Peroxisome proliferator-activated receptor gamma (PPAR-γ ; ) ; Amyloid-beta
- 刊名：Brain Research
- 出版年：2007
- 期刊代码：8_00068993
- 类别：neu
- 出版时间：10 October 2007
- 卷：1173
- 期：Complete
- 页码：1-5
- 文件大小：304 K
摘要
Mounting evidence suggests that peroxisome proliferator-activated receptor-γ (PPAR-γ) is involved in the modulation of pathogenic events related to Alzheimer's disease (AD). Such events would include the cerebral deposition of amyloid-β (Aβ) and the consequent local inflammatory response. PPAR-γ has been shown to act on both fronts, reducing either the secretion of Aβ or the expression of pro-inflammatory cytokines. Recently, the relatively common Pro12Ala polymorphism in exon 2 of PPAR-γ has been associated with higher risk for late onset AD. Here, we compare the effect of PPAR-γ and its genetic variant on the secretion of Aβ. Our results indicate that, in neuronal cultured cells, the Pro12Ala substitution does not affect the anti-amyloidogenic capacity of PPAR-γ. Additional factors, PPAR-γ related, may therefore predispose aged subjects, carrying the Ala allele, to develop the neurodegenerative disease.