Expanding the Boundaries of Embryonic Stem Cells

详细信息	查看全文 | 推荐本文 |

• 作者：Uri Ben-David¹ ; Oded Kopper¹ ; Nissim Benvenisty¹ ; ^{nissimb@cc.huji.ac.il}
• 刊名：Cell Stem Cell
• 出版年：2012
• 期刊代码：P15_19345909
• 类别：bio
• 出版时间：14 June, 2012
• 卷：10
• 期：6
• 页码：666-677
• 文件大小：2329 K

摘要

The boundaries of embryonic stem cell (ESC) research have extended considerably in recent years in several聽important ways. Alongside a deeper understanding of the pluripotent state, ESCs have been successfully integrated into various fields, such as genomics, epigenetics, and disease modeling. Significant progress in cell fate control has pushed directed differentiation and tissue engineering further than ever before and promoted clinical trials. The geographical distribution of research activity has also expanded, especially for human ESCs. This review outlines these developments and future challenges that remain.