Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference

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• 作者：Laura Font^a ; ^b ; ^{laura.font@uji.es} ; Christopher L. Cunningham^a
• 关键词：PRO ; Propranolol ; CPP ; Conditioned Place Preference ; 尾-AR ; 尾-adrenergic receptor ; CS ; Conditioned Stimulus ; US ; Unconditioned Stimulus ; IP ; Intraperitoneally ; G ; Grid ; T1 ; Test 1 ; Retrieval/Reactivation Test ; T2-Tn ; Test 2 to Test n ; Post-reconsolidatio
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2012
• 期刊代码：219_00913057
• 类别：med
• 出版时间：April, 2012
• 卷：101
• 期：2
• 页码：222-230
• 文件大小：619 K

摘要

The reconsolidation hypothesis posits that established emotional memories, when reactivated, become labile and susceptible to disruption. Post-retrieval injection of propranolol (PRO), a nonspecific 尾-adrenergic receptor antagonist, impairs subsequent retention performance of a cocaine- and a morphine-induced conditioned place preference (CPP), implicating the noradrenergic system in the reconsolidation processes of drug-seeking behavior. An important question is whether post-retrieval PRO disrupts memory for the drug-cue associations, or instead interferes with extinction. In the present study, we evaluated the role of the 尾-adrenergic system on the reconsolidation and extinction of ethanol-induced CPP. Male DBA/2J mice were trained using a weak or a strong conditioning procedure, achieved by varying the ethanol conditioning dose (1 or 2 g/kg) and the number of ethanol trials (2 or 4). After acquisition of ethanol CPP, animals were given a single post-retrieval injection of PRO (0, 10 or 30 mg/kg) and tested for memory reconsolidation 24 h later. Also, after the first reconsolidation test, mice received 18 additional 15-min choice extinction tests in which PRO was injected immediately after every test. Contrary to the prediction of the reconsolidation hypothesis, a single PRO injection after the retrieval test did not modify subsequent memory retention. In addition, repeated post-retrieval administration of PRO did not interfere with extinction of CPP in mice. Overall, our data suggest that the 尾-adrenergic receptor does not modulate the associative processes underlying ethanol CPP.