Perinatal outcome in cases of latent syphilis during pregnancy

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• 作者：Yonit Krakauer^a ; Gali Pariente^b ; ^{galipa@bgu.ac.il} ; Ruslan Sergienko^c ; Arnon Wiznitzer^b ; Eyal Sheiner^b
• 关键词：Fetal growth restriction ; Latent syphilis ; Pregnancy complications
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2012
• 期刊代码：130_00207292
• 类别：med
• 出版时间：July, 2012
• 卷：118
• 期：1
• 页码：15-17
• 文件大小：108 K

摘要

Objective

To investigate factors associated with latent syphilis and pregnancy outcome among women with latent syphilis.

Methods

A retrospective population-based study was conducted to compare all pregnancies among women with and without latent syphilis at Soroka University Medical Center, Be'er-Sheva, Israel, between 1988 and 2010. Stratified analysis using a multiple logistic regression model was performed to control for confounders.

Results

Of the 219 656 deliveries during the study period, 159 (0.1%) involved women with latent syphilis. Multivariate analysis with backward elimination revealed the following conditions to be significantly associated with latent syphilis: fetal growth restriction (odds ratio [OR] 2.20; 95%confidence interval [CI], 1.07-4.49; P = 0.03); drug abuse (OR 9.95; 95%CI, 1.31-75.46; P = 0.02); tobacco use (OR 3.35; 95%CI, 1.74-6.45; P < 0.05); and Jewish (vs Bedouin) ethnicity (OR 4.05; 95%CI, 2.65-6.20; P < 0.05).

Conclusion

Women with latent syphilis are at risk for adverse maternal and perinatal outcomes, including fetal growth restriction. Careful surveillance of these high-risk pregnancies should be considered.