Protection against heartwater by DNA immunisation with four Ehrlichia ruminantium open reading frames

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• 作者：A. Pretorius ; N.E. Collins ; H.C. Steyn ; F. van Strijp ; M. van Kleef ; B.A. Allsopp
• 关键词：Ehrlichia ruminantium ; DNA vaccination ; ABC transporters
• 刊名：Vaccine
• 出版年：2007
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：8 March 2007
• 卷：25
• 期：12
• 页码：2316-2324
• 文件大小：244 K

摘要

We have reported previously that a recombinant DNA vaccine consisting of four Ehrlichia ruminantium (Welgevonden) open reading frames (ORFs) known as the 1H12 cocktail provided protection against a virulent E. ruminantium (Welgevonden) needle challenge in sheep. In this study, we have investigated the vaccine effectiveness of two other cocktails of E. ruminantium (Welgevonden) ORFs, as well as single ORFs from the 1H12 cocktail, to protect sheep against a virulent needle challenge with the homologous strain. Each individual 1H12 ORF provided protection, but all the animals vaccinated with the other cocktails succumbed to the challenge.