As part of the PREMEVA randomized controlled trial, this population-based study included 14,193 women screened before 14 weeks鈥?gestation for bacterial vaginosis in the 160 laboratories of the Nord-Pas-de-Calais region in France. Bacterial vaginosis was defined by a Nugent score 鈮?#xA0;7. Data were collected about maternal tobacco use, age, education, and history of preterm birth. We estimated the prevalence of bacterial vaginosis and used a multilevel logistic regression model to identify significant risk factors for it.
Among the 14,193 women assessed before 14 weeks鈥?gestation, the prevalence of bacterial vaginosis was 7.1%(95%CI: 6.6-7.5%). In the multivariate analysis, smoking during pregnancy tobacco (adjusted OR: 1.38; 95%CI: 1.19-1.60), maternal age 18-19 years (adjusted OR: 1.40; 95%CI: 1.01-1.93), and educational level (completed only primary school: adjusted OR: 1.77; 95%CI: 1.35-2.31; completed only secondary school: adjusted OR: 1.27; 95%CI: 1.10-1.48) were independent risk factors for bacterial vaginosis. History of preterm delivery was not an independent risk factor of bacterial vaginosis: adjusted OR: 1.15; 95%CI: 0.90-1.47.
In a large sample of women in their first trimester of pregnancy in France, the prevalence of bacterial vaginosis was lower than rates reported in other countries, but risk factors were similar: young age, low level of education, and tobacco use during pregnancy. These results should be considered in future strategies to reduce preterm delivery.