• 作者：Marta Ulldemolins^a ; ^b ; ^c ; ^f ; Marcos I. Restrepo^d ; ^e ; ^{restrepom@uthscsa.edu} ; Jordi Rello^a ; ^b ; ^f
• 关键词：Infecci&oacute ; n nosocomial ; Unidad de Cuidados Intensivos ; Prevenci&oacute ; n de infecci&oacute ; n ; Antibi&oacute ; ticos ; Ventilaci&oacute ; n mecá ; nica
• 刊名：Medicina Cl铆nica
• 出版年：2011
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：15 January 2011
• 卷：136
• 期：1
• 页码：21-25
• 文件大小：189 K

Ventilator associated pneumonia is the principal infectious complication in the Intensive Care Unit (ICU), and represents the main infectious cause of morbidity and mortality. Its diagnosis and management is complex. Consequently, its prevention becomes a cornerstone in daily clinical practice. Daily interruption of sedation, oral and digestive decontamination, prophylactic administration of systemic and/or inhaled antibiotics, glycemic control, stress ulcer prophylaxis, transfusion policy and timing and adequacy of antibiotic treatment are the main suggested pharmacologic interventions.

The aim of this review is to critically describe the principal pharmacologic interventions for the prevention of ventilator associated pneumonia, focusing on the degree of the evidence and the appropriateness for daily clinical practice.