An efficient strategy for functionalized spirolactones and dispirodihydrofuranyl oxindoles using amines and activated alkynes

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• 作者：Selvarangam E. Kiruthika ; Rangarajan Amritha ; Paramasivan T. Perumal ; ^{ptperumal@gmail.com}
• 关键词：Huisgen dipolar additions ; Spirolactones ; Bisoxindoles ; Dihydrofurans ; Primary amines ; Activated alkynes
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：27 June, 2012
• 卷：53
• 期：26
• 页码：3268-3273
• 文件大小：788 K

摘要

A facile strategy for the synthesis of functionalized spirolactones from isatin, primary amines, and activated alkynes through Huisgen dipolar additions are discussed. A novel route for the formation of dispirodihydrofuranyl oxindoles from activated cyclic electrophiles, amines, and DMAD has also been developed. This method offers several advantages like high yield, readily available starting materials, and involves less hazardous chemical techniques.