One-pot four-component domino reaction for the synthesis of substituted dihydro-2-oxypyrrole catalyzed by molecular iodine

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• 作者：Abu T. Khan ; ^{atk@iitg.ernet.in} ; Arindam Ghosh ; Md. Musawwer Khan^&dagger ;
• 关键词：Multicomponent reactions ; Dihydro-2-oxypyrrole derivatives ; Dimethylacetylene dicarboxylate ; Primary amines ; Formaldehyde ; Iodine
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：23 May, 2012
• 卷：53
• 期：21
• 页码：2622-2626
• 文件大小：3890 K

摘要

The synthesis of multi-functionalized dihydro-2-oxypyrrole can be achieved using one-pot four-component domino reaction from dialkylacetylene dicarboxylate, amines, and formaldehyde by employing molecular iodine as catalyst at room temperature. The salient features of the present method are: simple, straightforward, cost-effective, environmentally benign, and no column chromatographic separation is applicable on a broad range of substrates.