Synthesis, X-ray structures, properties and SOD-like activity of ternary copper(II) complexes showing the N₄O₂ coordination with a combination of monodentate and bidentate N-donor ligands

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• 作者：Alena Klanicov&#225 ; ^a ; Joseph D. Houck^a ; Peter Baran^a ; ^b ; Zden&#283 ; k Tr&#225 ; vn&#237 ; &#269 ; ek^c ; ^{zdenek.travnicek@upol.cz}
• 关键词：DMF ; N ; N&prime ; -dimethylformamide ; DMSO ; dimethyl sulfoxide ; IC50 ; the concentration of complex or enzyme which causes 50%inhibition of XTT-formazan formation ; %INH ; percentage of inhibition ; SOD ; superoxide dismutase ; XTT ; 2 ; 3-bis(2-methoxy-4-nitro-5-su
• 刊名：Inorganica Chimica Acta
• 出版年：2012
• 期刊代码：40_00201693
• 类别：ch
• 出版时间：1 April, 2012
• 卷：384
• 期：Complete
• 页码：47-53
• 文件大小：608 K

摘要

A series of novel copper(II) complexes with the composition of [Cu(H₂O)₂(L_1-5)₂(phen)]路2MeOH (1-5), where HL₁ = 6-(2-fluorobenzylamino)purine, HL₂ = 6-(3-fluorobenzylamino)purine, HL₃ = 6-(4-fluorobenzylamino)purine, HL₄ = 6-(2-chlorobenzylamino)purine, HL₅ = 6-(3-chlorobenzylamino)purine, phen = 1,10-phenanthroline, was synthesized and characterized by elemental analysis, electronic and infrared spectroscopy, magnetic and conductivity measurements. Single-crystal X-ray analysis of complexes 1-4 showed the distorted octahedral geometry in the vicinity of the copper(II) atom, which is coordinated by four nitrogen atoms (two from the bidentate phen ligand and the other two from monodentate 6-(benzylamino)purine derivatives) and two oxygen atoms from the aqua ligands, which together form the N₄O₂ donor set. The antiradical activity of the prepared complexes was tested by an in vitro SOD-like assay. The IC₅₀ values were found ranging between 104 and 146 渭M, which represents ca. 0.5%of the native bovine Cu, Zn-SOD effect.