• 作者：Eduardo Aznar-Oroval^a ; Marina Sá ; nchez-Yepes^a ; ^{ma.sanchezy@comv.es} ; Pablo Lorente-Alegre^b ; Mari Carmen San Juan-Gadea^c ; Blanca Ortiz-Muñ ; oz^a ; Pilar Pé ; rez-Ballestero^a ; Isabel Picó ; n-Roig^b ; Joaquí ; n Maí ; quez-Richart^a ; ^c
• 关键词：Procalcitonina ; Proteí ; na C reactiva ; Bacteriemia ; Cá ; ncer
• 刊名：Enfermedades Infecciosas y Microbiolog铆a Cl铆nica
• 出版年：2010
• 期刊代码：pca153_0213005X
• 类别：med
• 出版时间：May 2010
• 卷：28
• 期：5
• 页码：273-277
• 文件大小：214 K

Background and Objective

Bacteremia is one of the most important causes of morbidity and mortality in cancer patients. The aim of this study was to evaluate the diagnostic usefulness of procalcitonin (PCT), interleukin 8 (IL-8), interleukin 6 (IL-6), and C-reactive protein (CRP) in the detection of bacteremia in cancer patients.

Patients and methods

PCT, IL-8, IL-6, and CPR levels were measured in 2 groups of cancer patients who had fever: one group with true bacteremia and another without bacteremia.

Results

Seventy-nine febrile episodes were analyzed in 79 patients, 43 men and 36 women. Forty-four patients were in the true bacteremia group. Significant differences in PCT (P<0.001), IL-8 (P<0.001), and IL-6 (P=0.002) values were found between patients with and without true bacteremia. CPR results were not significantly different between the groups (P=0.23). The cut-off point for PCT was 0.5 ng/mL and this parameter yielded the best specificity at 91.4%, with a sensitivity of 59.1%.

Conclusions

Among the infection markers studied, PCT provided the most information for diagnosing bacteremia in cancer patients.