Endometrial stromal sarcoma: Analysis of recurrence following adjuvant treatment

详细信息	查看全文 | 推荐本文 |

• 作者：Tiffany L. Beck^a ; Pankaj K. Singhal^e ; Hugh M. Ehrenberg^b ; ^c ; Peter G. Rose^b ; ^c ; ^d ; Shashikant B. Lele^e ; Thomas C. Krivak^a ; William C. McBee Jr.^a ; ^b ; ^c ; ^d ; ^{mcbeewc@comcast.net}
• 关键词：Endometrial stromal sarcoma ; Treatment ; Recurrence ; BSO
• 刊名：Gynecologic Oncology
• 出版年：2012
• 期刊代码：295_00908258
• 类别：med
• 出版时间：April, 2012
• 卷：125
• 期：1
• 页码：141-144
• 文件大小：217 K

摘要

Objective

Endometrial stromal sarcoma (ESS) is a rare and indolent form of uterine cancer with ill-defined post-operative treatment guidelines. The goal of this study was to evaluate the rate of recurrence and the effect of various adjuvant treatment modalities.

Methods

Patients with ESS at 4 institutions were identified (1986-2007). Patient demographics, pathology, treatment, and follow-up information were collected. Chi-square statistical analysis was performed.

Results

Forty-three patients with ESS were identified. All patients initially underwent hysterectomy. Twenty-eight (66.7%) had early stage, 12 (28.6%) had advanced stage ESS, and 2 (4.8%) had no staging information. Eight patients received pelvic and or vaginal cuff radiation treatment, with or without chemotherapy. Sixteen of 43 patients experienced a recurrence at an average of 100.5 months. Thirty-three patients were treated with progestin therapy alone or followed expectantly. Complete outpatient records were available for 28 of these patients. Sixteen patients (57%) were followed expectantly while 12 (43%) received progestins. Patients receiving progestins vs. expectant management had a lower rate of recurrence in stage 1 (14.3%vs 38.5%, p = 0.26) and all stages (33%vs 50%, p = 0.38). Twenty-three of 28 (82.1%) patients underwent initial oophorectomy. Eight of 23 (34.8%) had a recurrence, compared to 4 of 5 (80%) in those who retained their ovaries (p = 0.06).

Conclusions

ESS is a rare cancer that is difficult to study. We found removal of the adnexa and post-operative treatment with progestin therapy decreased recurrence rates. These two treatment strategies should be considered in the treatment of patients with all stages of ESS.