Prognostic significance of adhesion molecules (sICAM-1, sVCAM-1) and VEGF in colorectal cancer patients

详细信息	查看全文 | 推荐本文 |

• 作者：Violetta Dymicka-Piekarska^a ; ^{piekarskav@yahoo.com} ; Katarzyna Guzinska-Ustymowicz^b ; Adam Kuklinski^c ; Halina Kemona^a
• 关键词：CAM ; cell adhesion molecules ; ICAM ; intercellular adhesion molecule ; VCAM ; vascular cell adhesion molecule ; VEGF ; vascular endothelial growth factor ; CRC ; colorectal cancer
• 刊名：Thrombosis Research
• 出版年：2012
• 期刊代码：247_00493848
• 类别：med
• 出版时间：April, 2012
• 卷：129
• 期：4
• 页码：e47-e50
• 文件大小：313 K

摘要

Introduction

Adhesion molecules take part in the interaction between host cells and cancer cells. In the current study the relationship between the soluble adhesion molecules sICAM-1 and sVCAM-1 and proangiogenic factor VEGF in colorectal cancer progression were measured.

Materials and methods

The study group consisted of 46 patients with colorectal carcinoma (classified due to TNM classification) and 40 controls. sICAM-1, sVCAM-1 and VEGF plasma concentration were measured by enzyme-linked immunosorbent assay (ELISA).

Results

All measured parameters levels were increased significantly in patients with colorectal cancer in comparison to controls (p < 0.001). sICAM-1, sVCAM-1 and VEGF increased significantly due to colorectal cancer progression. There was a positive correlation between sICAM-1 and sVCAM-1 in all study groups.

Conclusions

Our results demonstrated in CRC patients significantly increased levels of soluble adhesion molecules (VCAM-1 and sICAM-1) and angiogenic factor (VEGF) as compared to control group. The dynamics of these molecules showed the growing tendency along with tumor size and metastasis formation.