PKC signaling in oxidative hepatic damage

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• 作者：Mariapaola Nitti ; Maria A. Pronzato ; Umberto M. Marinari ; Cinzia Domenicotti
• 关键词：Protein kinase C ; Liver ; Oxidative stress ; ROS ; Ethanol
• 刊名：Molecular Aspects of Medicine
• 出版年：2008
• 期刊代码：110_00982997
• 类别：bio
• 出版时间：February-April 2008
• 卷：29
• 期：1-2
• 页码：36-42
• 文件大小：127 K

摘要

Protein kinase C (PKC) is a family of isoenzymes differently involved in cell response to injury and many studies describe their role as “stress sensors”. Oxidative stress is strictly involved in the pathogenesis of chronic liver diseases including alcohol- or drug-induced hepatotoxicity, iron overload, hepatitis and hepatocarcinoma development, but molecular mechanisms are not really defined. A crucial role of PKC as a redox sensitive signaling molecule has been widely accepted.