Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents

详细信息	查看全文 | 推荐本文 |

• 作者：Tomas Hajek ; Eva Gunde ; Denise Bernier ; Claire Slaney ; Lukas Propper ; Paul Grof ; Glenda MacQueen ; Anne Duffy ; Martin Alda
• 关键词：Bipolar disorders ; MRI ; Subgenual cingulate ; High-risk
• 刊名：Journal of Affective Disorders
• 出版年：2008
• 期刊代码：141_01650327
• 类别：med
• 出版时间：June 2008
• 卷：108
• 期：3
• 页码：263-269
• 文件大小：146 K

摘要

Bipolar disorders (BD) have a strong genetic underpinning, yet no biological vulnerability markers for BD have been identified. Decreased volumes of subgenual cingulate (SGC) were replicated in familial bipolar patients. Presence of abnormality in unaffected subjects at genetic risk for an illness needs to be established before SGC volumes can be used as an endophenotype. This is the first study of SGC volumes in affected and unaffected subjects at familial risk for mood disorders.