Functional proton transfer pathways in the heme-copper oxidase superfamily

详细信息	查看全文 | 推荐本文 |

• 作者：Hyun Ju Lee ; Joachim Reimann ; Yafei Huang¹ ; Pia Ä ; delroth ; ^{piaa@dbb.su.se}
• 关键词：cbb3 ; aa3 ; ba3 ; NOR ; K-pathway ; Oxygen reduction
• 刊名：Biochimica et Biophysica Acta (BBA)/Bioenergetics
• 出版年：2012
• 期刊代码：13_00052728
• 类别：bio
• 出版时间：April, 2012
• 卷：1817
• 期：4
• 页码：537-544
• 文件大小：1237 K

摘要

Heme-copper oxidases (HCuOs) terminate the respiratory chain in mitochondria and most bacteria. They are transmembrane proteins that catalyse the reduction of oxygen and use the liberated free energy to maintain a proton-motive force across the membrane. The HCuO superfamily has been divided into the oxygen-reducing A-, B- and C-type oxidases as well as the bacterial NO reductases (NOR), catalysing the reduction of NO in the denitrification process. Proton transfer to the catalytic site in the mitochondrial-like A family occurs through two well-defined pathways termed the D- and K-pathways. The B, C, and NOR families differ in the pathways as well as the mechanisms for proton transfer to the active site and across the membrane. Recent structural and functional investigations, focussing on proton transfer in the B, C and NOR families will be discussed in this review. This article is part of a Special Issue entitled: Respiratory Oxidases.