Synthesis, DNA-binding, DNA-photonuclease profiling and antimicrobial activity of novel tetra-aza macrocyclic Ni(II), Co(II) and Cu(II) complexes constrained by thiadiazole

详细信息	查看全文 | 推荐本文 |

• 作者：B. Vinay Kumar^a ; H.S. Bhojya Naik^a ; ^{hsb_naik@rediffmail.com} ; D. Girija^a ; N. Sharath^a ; S.M. Pradeepa^a ; H. Joy Hoskeri^b ; M.C. Prabhakara^c
• 关键词：Tetra-aza macrocyclic ligand ; Metal complexes ; Antimicrobial activity ; DNA binding ; DNA photonuclease
• 刊名：Spectrochimica Acta Part A ; Molecular and Biomolecular Spectroscopy
• 出版年：2012
• 期刊代码：99_13861425
• 类别：ch
• 出版时间：August, 2012
• 卷：94
• 期：Complete
• 页码：192-199
• 文件大小：658 K

摘要

A new tetra-aza macrocyclic ligand, L (C₂₄H₁₆N₁₂O₂S₄) and its complexes of type, [MLCl₂] and [CuL]Cl₂ (where M = Ni(II), Co(II); L = N,N鈥?(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis{2-[(5-benzene-1,3-diyl-1,3,4-thiadiazol-2-yl)amino]acetamide}) were synthesized and characterized by the spectral and analytical techniques. An octahedral geometry has been proposed for Ni(II) and Co(II) complexes while Cu(II) complex exhibit a square planar geometry. All the synthesized metal complexes were screened for their in vitro antimicrobial activity against selected species of pathogenic bacteria and fungi. The binding property of the complexes with CT-DNA was studied by absorption spectral analysis, followed by viscosity measurement and thermal denaturation studies. The photo induced cleavage studies revealed that the complexes possess photonuclease property against pUC19 DNA under UV-visible irradiation.