- 作者：F. Pugliese ; F. Ruberto ; D. Summonti ; S. Perrella ; A. Cappannoli ; A. Tosi ; A. D’ ; alio ; K. Bruno ; S. Martelli ; P. Celli ; V. Morabito ; M. Rossi ; P.B. Berloco ; P. Pietropaoli
- 关键词：Blood transfusion ; Evaluation of the professional practices ; Continuous medical training
- 刊名：Transplantation Proceedings
- 出版年：2007
- 期刊代码：252_00411345
- 类别：med
- 出版时间：July-August 2007
- 卷：39
- 期：6
- 页码：1883-1885
- 文件大小：60 K
ss="h4">Methods
Twenty OLT patients were assigned in double-blind way to a rFVIIa group or a control group. Inclusion criteria were hemoglobin > 8 g/dL: INR > 1,5 and fibrinogen > 100 mg/dL. We administered a single bouls of rFVIIa (40 μg/kg) or placebo. We determined INR, partial thromboplastin time, fibrinogen, ATIII, and blood cell counts. Blood products were administered as follows: 4 units of fresh frozen plasma when INR > 1.5, and 1 unit of RBC for Hb < 10 g/dL. The study ended 6 hours after the bolus.
ss="h4">Results
No thromboembolic events occurred. The INR was different between rFVIIa group and the controls at T0 (1.9 vs 1.6 P < .021) and during T1 (1.2 vs 1.6 P < .004). The total transfused red blood cells was 300 mL ± 133 in rFVIIa group and 570 mL ± 111 in control group (P < .017). The total fresh frozen plasma was 600 mL ± 154 in rFVIIa group and 1400 mL ± 187 in control group (P < .001). Total blood loss was greater in the control group than the rFVIIa group: 1140 mL ± 112 vs 740 mL ± 131 (P < .049).
ss="h4">Discussion
The use of rFVIIa during OLT can reduce the risk of bleeding during surgery. The literature has described cases who did not benefit from the treatment. An adequate cut-off of INR, allowed us to treat only patients at greater bleeding risk.