MRI-Guided 3D Optimization Significantly Improves DVH Parameters of Pulsed-Dose-Rate Brachytherapy in Locally Advanced Cervical Cancer
- 作者：Jacob C. Lindegaard ; Kari T ; erup ; Sø ; ren Kynde Nielsen ; Sø ; ren Haack ; John Gelineck
- 关键词：Pulsed-dose-rate brachytherapy ; Cervical cancer ; Image guided ; Treatment planning ; Magnetic resonance imaging ; MRI
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2008
- 期刊代码：136_03603016
- 类别：med
- 出版时间：1 July 2008
- 卷：71
- 期：3
- 页码：756-764
- 文件大小：872 K
摘要
A major stumbling block in the applications of enantiomerically pure Tröger's base analogues is their poor availability. We have therefore developed a facile method for the enantioseparation of functionalized Tröger's base analogues possessing various substitution patterns. The systematic separation of a library comprising 36 representatives on the commercially available Whelk O1 chiral stationary phase provided valuable information on structure–enantioselectivity relationships. A mechanistic explanation of observed relationships allows one to predict whether or not enantioseparation of a given, perhaps yet unknown derivative of Tröger's base will be feasible. In addition, we provide a detailed report on the scope and limitations of the general synthetic protocol employing anilines and paraformaldehyde in CF3COOH, as well as some considerations concerning the mechanism of formation of Tröger's base analogues.