Photoaging as a consequence of natural and therapeutic ultraviolet irradiation—studies on PUVA-induced senescence-like growth arrest of human dermal fibroblasts
- 作者：Wlaschek ; Meinhard ; Ma ; Wenjian ; Jansen-Dü ; rr ; Pidder ; Scharffetter-Kochanek ; Karin
- 关键词：Fibroblast ; Photoaging ; In vivo ; Psoralen ; Senescence
- 刊名：Experimental Gerontology
- 出版年：2003
- 期刊代码：99_05315565
- 类别：med
- 出版时间：November - December, 2003
- 卷：38
- 期：11-12
- 页码：1265-1270
- 文件大小：106 K
摘要
Premature aging of the skin is a prominent side effect of psoralen photoactivation, a therapy widely and successfully used for different skin disorders. Recently, we demonstrated that treatment of fibroblasts with 8-methoxypsoralen and ultraviolet A irradiation resulted in growth arrest with morphological and functional changes reminiscent of replicative senescence. In this minireview we will focus on the similarities between intrinsic and extrinsic aging and PUVA-induced senescence-like growth arrest both resulting in the loss of the structural integrity of the dermal connective tissue as a hallmark of intrinsic aging and photoaging (extrinsic aging) of the skin, and we will discuss the important role of oxidative stress related telomere attrition in the PUVA-induced phenotype of dermal fibroblasts.