Bis(3-hydroxy-4-pyridinone)-EDTA derivative as a potential therapeutic Al-chelating agent. Synthesis, solution studies and biological assays

详细信息	查看全文 | 推荐本文 |

• 作者：M. Amé ; lia Santos ; Sofia Gama ; Lurdes Gano and Etelka Farkas
• 关键词：3-hydroxy-4-pyridinones ; Hydroxypyridinonate complexes ; Al-chelator ; Chelating agent
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2005
• 期刊代码：53_01620134
• 类别：ch
• 出版时间：2005
• 卷：99
• 期：9
• 页码：1845-1852
• 文件大小：316 K

摘要

The 3-hydroxy-4-pyridinones are chelating agents of current interest due to their high affinity for hard metal ions and potential clinical applications as metal-decorporation agents. A new bis-(3-hydroxy-4-pyridinone) derivative of EDTA have been developed, and herein we describe the results of solution studies to determine the protonation constants and the partition coefficient. Biodistribution studies, performed with ⁶⁷Ga-overload mice, showed rapid clearance of the radiotracer from the body, thus indicating that the new ligand should be a quite effective agent for the in vivo aluminium removal.