Towards a new attenuating compound: A potentiometric, spectrophotometric and NMR equilibrium study on Fe(III), Al(III) and a new tetradentate mixed bisphosphonate–hydroxypyridinonate ligand
- 作者：Guido Crisponi ; Valeria Marina Nurchi ; Tiziana Pivetta ; Joanna Gał ; ę ; zowska ; Elż ; bieta Gumienna-Kontecka ; Thé ; odorine Bailly ; Ramon Burgada ; Henryk Kozł ; owski
- 关键词：Fe(III) complexes ; Al(III) complexes ; Bisphosphonates ; 1-Hydroxy-2(1H)-pyridinone ; Chelating agents ; Potentiometry ; Spectrophotometry ; Quantum mechanical calculations
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2008
- 期刊代码：53_01620134
- 类别：ch
- 出版时间：July 2008
- 卷：102
- 期：7
- 页码：1486-1494
- 文件大小：615 K
摘要
Coordination properties toward Fe(III) and Al(III) of a mixed bisphosphonate–hydroxypyridinonate ligand are presented. Potentiometric, spectrophotometric and NMR results allowed to conclude that Fe(III) and Al(III) coordination takes place on the pyridinone moiety. The high steric hindrance prevents the possibility of simultaneous coordination of both groups to the same metal ion. Quantum mechanical calculations confirm this finding allowing to determine the minimal length of the linker necessary for a stable conformation of complexes in which Fe(III) is coordinated both by pyridinone and bisphosphonate groups.