Solid-phase synthesis of phenols and pyridinones via arylboronation/oxidation protocol using aryl bromides

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• 作者：Younghee Lee and Martha J. Kelly
• 关键词：Solid-phase synthesis ; Arylboronation ; Oxidation ; Phenol ; Pyridinone
• 刊名：Tetrahedron Letters
• 出版年：2006
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：12 July 2006
• 卷：47
• 期：28
• 页码：4897-4901
• 文件大小：156 K

摘要

A sequence of two known reactions, palladium catalyzed arylboronation of arybromide and subsequent oxidation of arylboronate with oxone, has been carried out to prepare functionalized phenols and pyridin-2(1H)-one which were later loaded on to resin for solid-phase synthesis. Using these resin-bound templates, a number of solid-phase methods were developed to generate libraries of substituted phenols and pyridin-2(1H)-one.