An efficient synthesis of 2H-indazoles via reductive cyclization of 2-nitrobenzylamines induced by low-valent titanium reagent

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• 作者：Fang Sun ; Xian Feng ; Xuan Zhao ; Zhi-Bin Huang ; Da-Qing Shi ; ^{dqshi@263.net}
• 关键词：2H-Indazole ; 2-Nitrobenzylamine ; Reductive cyclization ; Low-valent titanium reagent
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：20 May, 2012
• 卷：68
• 期：20
• 页码：3851-3855
• 文件大小：333 K

摘要

An efficient and improved synthesis of 2H-indazoles via reductive cyclization of 2-nitrobenzylamines induced by low-valent titanium reagent (TiCl₄/Zn) is described. In this reaction triethylamine (TEA) was used to control the pH value. This method has the advantages of easily accessible starting materials, convenient manipulation, higher yield, shorter reaction time, and wider substrate scope.