Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features

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• 作者：Anna Leszczy艅ska-Rodziewicz^a ; ^b ; ^{alrodziewicz@ump.edu.pl} ; Aleksandra Szczepankiewicz^b ; ^c ; Monika Dmitrzak-W臋glarz^b ; Maria Skibi艅ska^b ; Joanna Hauser^b
• 关键词：Psychotic features ; NR3C1 gene ; AVPR1b gene ; CRHR1 gene
• 刊名：Journal of Affective Disorders
• 出版年：2012
• 期刊代码：141_01650327
• 类别：med
• 出版时间：May, 2012
• 卷：138
• 期：3
• 页码：490-493
• 文件大小：139 K

摘要

Background

An association between HPA 鈥?axis disturbances and susceptibility towards depression with psychotic features has been reported. NR3C1, CRHR1 and AVPR1b are the key components of this system. We investigated the possible involvement of the polymorphisms of those genes with the susceptibility to psychotic features in the course of BP I disorder.

Methods

The study was conducted on 194 patients with psychotic features in the course of BPI. Control group consisted of 732 healthy subjects. Genotyping for NR3C1, AVPR1b and CRHR1 polymorphisms was done with use of TagMan SNP Genotyping Assays.

Results

The association of polymorphisms rs28536160 genotype TT of the AVPR1b gene and polymorphisms rs1293651 of CRHR1 gene with psychotic features in the course of BPI.

Limitations

The main limitation of our study is the small sample size of the group of patients with psychotic features.

Conclusions

The results of our study suggest that the studied polymorphisms may increase susceptibility for obtaining psychotic features in the course of BP I.