O-Seco-RA-XXIV, a possible precursor of an antitumor peptide RA-XXIV, from Rubia cordifolia L.

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• 作者：Yukio Hitotsuyanagi ; Jun-ichi Kusano ; Ik-Hwi Kim ; Tomoyo Hasuda ; Haruhiko Fukaya ; Koichi Takeya ; ^{takeyak@ps.toyaku.ac.jp}
• 关键词：Antitumor ; Bouvardin ; O-Seco-RA-XXIV ; RA-VII ; RA-XXIV ; Rubia cordifolia
• 刊名：Phytochemistry Letters
• 出版年：2012
• 期刊代码：P8_18743900
• 类别：abs
• 出版时间：June, 2012
• 卷：5
• 期：2
• 页码：335-339
• 文件大小：554 K

摘要

O-Seco-RA-XXIV, a new cyclic peptide, cyclo-(d-alanyl-l-glutaminyl-N,O-dimethyl-l-tyrosyl-l-alanyl-N-methyl-l-tyrosyl-N-methyl-l-tyrosyl), was isolated from the roots of Rubia cordifolia L. along with RA-XXIV. Its structure and relative stereochemistry were determined by interpretation of the spectroscopic data and X-ray crystallography, and its absolute stereochemistry by the Marfey's amino acid analysis of its acid hydrolysate. Isolation of the two peptides from the same plant source may indicate that O-seco-RA-XXIV is a possible precursor of RA-XXIV and that the formation of the diphenyl ether linkage in the cycloisodityrosine moiety is to be formed after the formation of the cyclohexapeptide chain in this series of peptides.