Evaluation of microalbuminuria after non-ionic radiocontrast medium exposure in patients undergoing coronary angiography
- 作者：Kai-Hong Cheng ; Chih-Sheng Chu ; Kun-Tai Lee ; Tsung-Hsien Lin ; Wen-Chol Voon ; Li-Yu Tsai ; Sheng-Hsiung Sheu ; Wen-Ter Lai
- 关键词：Microalbuminuria ; Radiocontrast medium ; Coronary arteriography
- 刊名：International Journal of Cardiology
- 出版年：2008
- 期刊代码：128_01675273
- 类别：med
- 出版时间：23 June 2008
- 卷：127
- 期：1
- 页码：126-128
- 文件大小：139 K
摘要
Transient and massive glomerular proteinuria, previously reported as one of the nephrotoxic reactions after ionic radiocontrast medium (RCM) exposure, is rarely observed in patients since the introduction of non-ionic RCM. However, whether the very low-range microalbuminuria might be encountered after non-ionic RCM exposure remains unknown. In this study we sought to investigate the effects of non-ionic RCM (Ultravist 370) exposure on the presence of microalbuminuria, defined as urine albumin-to-creatinine ratio (UACR) > 30 mg/g, by a turbidmetric method in total of 64 patients (17 female, mean age 58 ± 12 years) undergoing coronary angiography. The results showed that after non-ionic RCM (mean volume 103 ± 57 ml) exposure, no significant differences were found in urinary albumin concentration or UACR; however, urinary creatinine was significantly reduced from 116 ± 62 to 69 ± 43 mg/dl (p < 0.001). Changes in the presence of microalbuminuria before and after procedure were also not significant (p = 0.891, McNemar test). In conclusion, non-ionic RCM exposure during CAG had negligible effect on the excretion of urinary albumin even within the detection range of microalbuminuria.