Effectiveness of intensity-modulated and image-guided radiotherapy to spare the mandible from excessive radiation

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• 作者：Nam P. Nguyen^a ; ^{NamPhong.Nguyen@yahoo.com} ; Jacqueline Vock^b ; Alexander Chi^a ; Lars Ewell^a ; Paul Vos^c ; Melissa Mills^a ; Rihan Khan^d ; Fabio Almeida^a ; Rick Davis^a ; Michael Betz^e ; Siyoung Jang^a ; Steve Gelumbauskas^a ; Richard P. Vo^f ; Vincent Vinh-Hung^e
• 关键词：Head and neck cancer ; IMRT ; IGRT ; Osteoradionecrosis
• 刊名：Oral Oncology
• 出版年：2012
• 期刊代码：213_13688375
• 类别：med
• 出版时间：July, 2012
• 卷：48
• 期：7
• 页码：653-657
• 文件大小：376 K

摘要

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Summary

We would like to assess the effectiveness of intensity-modulated radiotherapy (IMRT) or image-guided radiotherapy (IGRT) to decrease the risk of osteoradionecrosis in locally advanced head and neck cancer. We conducted a retrospective study of 83 patients with head and neck cancer undergoing concurrent definitive chemoradiation, post-operative radiotherapy or chemoradiation, or radiotherapy alone with IMRT or IGRT. Mean mandibular dose was, respectively, 43.6 Gy and 43.8 Gy for the IMRT and IGRT technique. At a median follow-up of 28 months (5-55 months), only one patient developed osteoradionecrosis requiring hyperbaric oxygen. Sharp dose falloff associated with IMRT and IGRT decreased excessive radiation of the mandible and may reduce the risks of osteoradionecrosis.