Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism

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• 作者：Pratap Rudra ; M.P. ; Raghuveer Singh ; M. ; Junaid ; M.A. ; Jyothi ; P. ; Rao ; S.L.N.
• 关键词：Lathyrus sativus ; Neurolathyrism ; Neurotoxin ; ODAP ; ODAP metabolism ; Detoxification
• 刊名：Clinical Biochemistry
• 出版年：2004
• 期刊代码：55_00099120
• 类别：med
• 出版时间：April, 2004
• 卷：37
• 期：4
• 页码：318-322
• 文件大小：197 K

摘要

Objectives: The reasons for the very low incidence of the disease neurolathyrism in humans even after excessive consumption of the pulse, Lathyrus sativus, under severe drought and famine conditions, and its continued consumption by large populations during normal periods without any deleterious effects have been examined in the context of a possible metabolism or detoxification of β-N-oxalyl-l-α, β-diaminopropionic acid (ODAP), the major neurotoxic amino acid of L. sativus.