Effect of hyperhomocysteinemia induced by methionine administration on flow-mediated dilatation of the brachial artery in healthy subjects
- 作者：Al-Shaer ; Moutasim H. ; Raghuveer ; Geetha ; Browning ; Roger ; Sinkey ; Christine A. ; Chenard ; Catherine ; et. al.
- 刊名：The American Journal of Cardiology
- 出版年：2005
- 期刊代码：5_00029149
- 类别：med
- 出版时间：February 1, 2005
- 卷：95
- 期：3
- 页码：428-430
- 文件大小：177 K
摘要
Homocysteine may contribute to systolic hypertension and cardiac events by decreasing conduit artery compliance and inducing endothelial dysfunction. The effects of the experimental induction of hyperhomocysteinemia on systemic arterial compliance and pulsewave velocity are unclear, with contradictory results from previous studies. The investigators tested whether oral methionine impairs brachial artery compliance in addition to endothelial function.