Synthesis, spectral characterization and larvicidal activity of acridin-1(2H)-one analogues

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• 作者：R. Subashini^a ; A. Bharathi^a ; Selvaraj Mohana Roopan^a ; ^{mohanaroopan.s@gmail.com} ; G. Rajakumar^b ; A. Abdul Rahuman^b ; ^{abdulrahuman6@hotmail.com} ; Pavan Kumar Gullanki^a
• 关键词：Synthesis ; Acridin-1(2H)-one ; NMR ; Mass ; Vector
• 刊名：Spectrochimica Acta Part A ; Molecular and Biomolecular Spectroscopy
• 出版年：2012
• 期刊代码：99_13861425
• 类别：ch
• 出版时间：September, 2012
• 卷：95
• 期：Complete
• 页码：442-445
• 文件大小：186 K

摘要

Acridin-1(2H)-one analogue of 7-chloro-3,4-dihydro-9-phenyl-2-[(pyridine-2yl) methylene] acridin-1(2H)-one, 5 was prepared by using 7-chloro-3,4-dihydro-9-phenylacridin-1(2H)-one, 3 and picolinaldehyde, 4 in the presence of KOH at room temperature. These compounds were characterized by analytical and spectral analyses. The purpose of the present study was to assess the efficacy of larvicidal and repellent activity of synthesized 7-chloro-3,4-dihydro-9-phenyl-acridin-1(2H)-one analogues such as compounds 3 and 5 against the early fourth instar larvae of filariasis vector, Culex quinquefasciatus and Japanese encephalitis vector, Culex gelidus (Diptera: Culicidae). The compound exhibited high larvicidal effects at 50 mg/L against both the mosquitoes with LC₅₀ values of 25.02 mg/L (r² = 0.998) and 26.40 mg/L (r² = 0.988) against C. quinquefasciatus and C. gelidus, respectively. The 7-chloro-3,4-dihydro-9-phenyl-acridin-1(2H)-one analogues that are reported for the first time to our best of knowledge can be better explored for the control of mosquito population. This is an ideal ecofriendly approach for the control of Japanese encephalitis vectors, C. quinquefasciatus and C. gelidus.