Effect of secondhand smoke on asthma control among black and Latino children

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• 作者：Sam S. Oh ; PhD ; MPH^a ; ^b ; ^{Sam.Oh@ucsf.edu} ; Haig Tcheurekdjian ; MD^c ; ^d ; Lindsey A. Roth ; MA^a ; Elizabeth A. Nguyen ; BS^a ; Saunak Sen ; PhD^e ; Joshua M. Galanter ; MD^a ; Adam Davis ; MA ; MPH^f ; Harold J. Farber ; MD ; MSPH^g ; Frank D. Gilliland ; MD ; PhD^h ; Rajesh Kumar ; MD ; MSⁱ ; Pedro C. Avila ; MD^j ; Emerita Brigino-Buenaventura ; MD^k ; Rocio Chapela ; MD^l ; Jean G. Ford ; MD^m ; Michael A. LeNoir ; MDⁿ ; Fred Lurmann ; MS^o ; Kelley Meade ; MD^f ; Denise Serebrisky ; MD^p ; Shannon Thyne ; MD^q ; William Rodriguez-Cintron ; MD^r ; Jose R. Rodriguez-Santana ; MD^s ; L. Keoki Williams ; MD ; MPH^t ; ^u ; Luisa N. Borrell ; DDS ; PhD^v ; Esteban G. Burchard ; MD ; MPH^a
• 关键词：Secondhand smoke ; prenatal exposure delayed effects ; asthma ; health status disparities
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2012
• 期刊代码：158_00916749
• 类别：med
• 出版时间：June, 2012
• 卷：129
• 期：6
• 页码：1478-1483.e7
• 文件大小：195 K

摘要

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Background

Among patients with asthma, the clinical effect and relative contribution of maternal smoking during pregnancy (in utero smoking) and current secondhand smoke (SHS) exposure on asthma control is poorly documented, and there is a paucity of research involving minority populations.

Objectives

We sought to examine the association between poor asthma control and in utero smoking and current SHS exposure among Latino and black children with asthma.

Methods

We performed a case-only analysis of 2 multicenter case-control studies conducted from 2008-2010 with similar protocols. We recruited 2481 Latino and black subjects with asthma (ages 8-17 years) from the mainland United States and Puerto Rico. Ordinal logistic regression was used to estimate the effect of in utero smoking and current SHS exposures on National Heart, Lung, and Blood Institute-defined asthma control.

Results

Poor asthma control among children 8 to 17 years of age was independently associated with in utero smoking (odds ratio [OR], 1.5; 95%CI, 1.1-2.0). In utero smoking through the mother was also associated with secondary asthma outcomes, including early-onset asthma (OR, 1.7; 95%CI, 1.1-2.4), daytime symptoms (OR, 1.6; 95%CI, 1.1-2.1), and asthma-related limitation of activities (OR, 1.6; 95%CI, 1.2-2.2).

Conclusions

Maternal smoking while in utero is associated with poor asthma control in black and Latino subjects assessed at 8-17 years of age.