Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals
- 作者：Gupta ; Rajesh Kumar ; Kesari ; Achyut Narayan ; Murthy ; P.S. ; Chandra ; R. ; Tandon ; V. ; Watal ; Geeta
- 关键词：Annona squamosa ; Diabetes ; Alloxan ; Streptozotocin ; Glucose tolerance test
- 刊名：Journal of Ethnopharmacology
- 出版年：2005
- 期刊代码：26_03788741
- 类别：pha
- 出版时间：May 13, 2005
- 卷：99
- 期：1
- 页码：75-81
- 文件大小：125 K
摘要
The ethanolic extract of Annona squamosa L. (Annonaceae) leaves was administered orally at different doses to normal as well as streptozotocin (STZ)-induced diabetic rats and alloxan-induced diabetic rabbits. The dose of 350 mg/kg body weight (bw) reduced the fasting blood glucose (FBG) level by 6.0%within 1 h, whereas, the peak blood glucose at 1 h during glucose tolerance test (GTT) was reduced by 17.1%in normal rats. The same dose of ethanolic extract reduced FBG by 26.8%and improved glucose tolerance by 38.5 and 40.6%at 1 and 2 h, respectively, during GTT in alloxan-induced diabetic rabbits. In STZ-diabetic rats, a fall of 13.0%in FBG and an improvement in glucose tolerance by 37.2 and 60.6%at 1 and 2 h, respectively, was observed during GTT. The dose of 350 mg/kg bw of ethanolic extract in 10-day treatment of a group of STZ-diabetic rats produced 73.3%fall in FBG level and no sugar was observed in fasting urine. Treatment of severely-diabetic rabbits for 15 days with a dose of 350 mg/kg of extract reduce FBG by 52.7%and urine sugar by 75%. It brought about fall in the level of total cholesterol (TC) by 49.3%with increase of 30.3%in high-density lipoprotein (HDL) and decrease of 71.9 and 28.7%in low-density lipoprotein (LDL) and triglycerides (TG) levels, respectively.