• 作者：I. Castillo Romera^a ; ^{Icastillo.hgugm@salud.madrid.org} ; A. Ais Larisgoitia^a ; A.N. Trovato Ló ; pez^a ; V. Escudero Villaplana^a ; J.M. Belló ; n Cano^b ; M. Sanjurjo Saé ; z^a
• 关键词：Darunavir ; Maraviroc ; Etravirina ; Raltegravir ; Resistencia multiple a medicamentos ; Tratamiento antirretroviral ; Infecció ; n por VIH
• 刊名：Farmacia Hospitalaria
• 出版年：2011
• 期刊代码：pca388_11306343
• 类别：pha
• 出版时间：January-February 2011
• 卷：35
• 期：1
• 页码：14-22
• 文件大小：342 K

Objective

To describe the indications for use, in medical practice, of next-generation antiretroviral drugs (NGA): darunavir, raltegravir, maraviroc and etravirine.

Method

An observational, transversal and descriptive study conducted in adult patients who have started to receive a NGA between May 2008 and April 2009. The variables associated with the use of NGA were defined as follows: a) Variables related to efficacy: resistance confirmed by geno/phenotype tests or potencial resistance as a result of extensive exposure to antiretroviral agents, and/or severe immunological deterioration (CD4 less than 200 cells/mcl). b) Variables related to safety: prior toxicity to classic antiretroviral drugs and/or comorbidity which compromises their use. c) Combined efficacy and safety variable (main variable): prioritizing the variables which were detected, the patients were classified into three groups: multiresistant geno/phenotype (multi-G/P), multiresistant as a result of treatment history and other situations. Data was obtained from electronic medical records, laboratory tests, and records of interviews and drugs dispensed by the Pharmacy Service.

Results

Seventy three patients, 40%of whom had an undetectable viral load and 38.4%who showed severe immunological deterioration, were included in the study. Multi-G/P occurred in 45%and multiresistance as a result of treatment history was found in 33%of patients. Patients classified as belonging to the 鈥渙ther situations鈥?category were characterized by having a greater viral load and a poorer immunological status. In 90%of the patients without multi-G/P two or more variables associated with the use of NGA were detected.

Discussion

The medical reality of using NGA shows that they play a role in clinical situations which are very different, specific and difficult to manage.