• 作者：C. Ramos-Font^a ; ^{carlos.ramos.font.ext@juntadeandalucia.es} ; M. Gó ; mez R&#237 ; o^b ; A. Rodr&#237 ; guez-Ferná ; ndez^b ; R. Sá ; nchez Sá ; nchez^b ; J.M. Llamas Elvira^b
• 关键词：Tomografí ; a por emisió ; n de positrones ; PET ; PET-TAC ; 18F-fluordesoxiglucosa ; Cá ; ncer de vesí ; cula ; Estadificació ; n ; Imagen diagnó ; stica
• 刊名：Revista Espa帽ola de Medicina Nuclear
• 出版年：2011
• 期刊代码：pca315_02126982
• 类别：med
• 出版时间：September-October 2011
• 卷：30
• 期：5
• 页码：267-275
• 文件大小：931 K

Background

Gallbladder carcinoma is a neoplasm having a poor prognosis in which the role of the positron emission tomography with ¹⁸F-fluordeoxyglucose as a diagnostic tool, although of possible usefulness, has not been well-defined.

Methods/design

It is a prospective cohort of patients with radiologically malignant suspicious gallbladder lesions. A staging diagnostic presurgical FDG-PET study was carried out in each patient using both dedicated PET and multimodality PET-CT scanners. Diagnostic accuracy parameters were calculated from the results of PET imaging and were correlated with the condition and/or the clinical course of the patients. The clinical impact of its implementation in the diagnosis of gallbladder carcinoma was also analyzed.

Results

A total of 42聽patients were recruited (22聽malignant lesions, 20聽benign). Overall diagnostic accuracy was 83.33%for the diagnosis of the primary lesion, 88.89%for the evaluation of lymph node involvement and 85.1%for the evaluation of metastatic disease. Mean SUVmax in malignant gallbladder lesions was 6.14 卤 2.89. ROC curve showed a cut-off value of 3.65 in the SUVmax for malignancy. Accuracy of PET studies alone (n = 21) was slightly lower than that of the PET/CT (n = 21). FDG-PET changed the management of 14.8%of the population due to the identification of unsuspected metastatic disease.

Comments

FDG-PET accurately diagnoses malignancy or benignity of suspicious gallbladder lesions, with the addition of its capacity to identify unsuspected metastatic disease. PET-CT improves the diagnostic accuracy of the procedure, due to the metabolic-structural complementarity of their information. The SUVmax has a complementary value added to the visual analysis.