Macronutrients, fatty acids, cholesterol, and risk of benign prostatic hyperplasia

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• 作者：Francesca Bravi ; Cristina Bosetti ; Luigino Dal Maso ; Renato Talamini ; Maurizio Montella ; Eva Negri ; Valerio Ramazzotti ; Silvia Franceschi and Carlo La Vecchia
• 刊名：Urology
• 出版年：2006
• 期刊代码：267_00904295
• 类别：med
• 出版时间：June 2006
• 卷：67
• 期：6
• 页码：1205-1211
• 文件大小：117 K

摘要

Objectives

To better understand the role of specific macronutrients on the risk of benign prostatic hyperplasia (BPH), we used data from an Italian case-control study. Although BPH is extremely common among the elderly, its etiology—and, particularly, the role of diet and specific macronutrients—is still unclear.

Methods

A case-control study of 1369 patients with BPH and 1451 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions, was conducted in Italy. The subjects’ usual diet was investigated through a validated and reproducible food frequency questionnaire. Multivariate odds ratios (ORs) and 95%confidence intervals (CIs) were obtained after allowance for energy intake and other potential confounding factors.

Results

A significant direct relation was observed between starch intake (OR 1.51, 95%CI 1.15 to 1.99 for highest quintile compared with lowest one), and an inverse relation was observed for polyunsaturated fatty acids (OR 0.72, 95%CI 0.55 to 0.93), linoleic acid (OR 0.73, 95%CI 0.56 to 0.94), and linolenic acid (OR 0.71, 95%CI 0.54 to 0.93).

Conclusions

The results of this study suggest a role for specific macronutrients in the risk of BPH, including, in particular, an unfavorable effect for starch and a beneficial one for polyunsaturated fatty acids.