Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice

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• 作者：Lees ; Catherine J. ; Apostolopoulos ; Vasso ; Acres ; Bruce ; Ramshaw ; Ian ; Ramsay ; Alistair ; Ong ; Chin.-Swee ; et. al.
• 关键词：Cytokines ; Transgenic ; MUC1 ; MUC1 ; human mucin 1 ; M-FP ; mannan-MUC1 fusion protein ; A2-MUC1 ; HLA-A*0201× ; MUC1 double transgenic mouse ; CTLp ; CTL precursor ; VV ; vaccinia virus
• 刊名：Vaccine
• 出版年：2000
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：September 15, 2000
• 卷：19
• 期：2-3
• 页码：158-162
• 文件大小：142 K

摘要

Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8⁺ cytotoxic T cells. We now demonstrate that in MUC1/HLA-A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice.