3′ UTR (AGG)_n repeat of glial cell line-derived neurotrophic factor (GDNF) gene polymorphism in schizophrenia

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• 作者：Michelato ; Anna ; Bonvicini ; Cristian ; Ventriglia ; Mariacarla ; Scassellati ; Catia ; Randazzo ; Roberto ; et. al.
• 关键词：Neurotrophic factor ; Protective factors ; Association study ; Italian population
• 刊名：Neuroscience Letters
• 出版年：2004
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：March 11, 2004
• 卷：357
• 期：3
• 页码：235-237
• 文件大小：77.9 K

摘要

Association studies on gene polymorphisms of neurotransmitter systems have hypothesized an involvement of dopamine receptors in susceptibility to schizophrenia. However, structural and morphological abnormalities in different brain regions of schizophrenic patients support neurodevelopmental etiology for schizophrenia and neurotrophic factor genes could be candidates for genetic studies. The glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic and potential differentiation factor for dopaminergic systems. We have performed, in an Italian sample, an association study on 3′ UTR (AGG)_n repeat in GDNF gene. Our results have evidenced a difference in the allele frequencies between patients and controls (CLUMP (T1) χ²